Human reproductive and prenatal genetics

Intro -- Human Reproductive and Prenatal Genetics -- Copyright -- Contents -- Contributors -- Preface -- Part I: Reproductive tract development and gametogenesis -- Chapter 1: Developmental genetics of the male reproductive system -- Introduction -- Gonadal development -- Early testicular development -- Testicular descent -- Transabdominal phase -- Inguinoscrotal phase -- Genetic control of testicular descent -- Insulin like 3 (INSL3) -- Androgen receptor (AR) -- Calcitonin gene-related peptide (CGRP) -- E2F transcription factor 1 (E2F1) -- Anti-Müllerian hormone (AMH) -- Fibroblast growth factors (FGF), Homeobox (Hox), wingless (Wnt), Notch -- Development of the external genitalia -- Formation of the genital tubercle -- Formation of the male urethra -- Differentiation of the male and female genitalia -- Genetic control of external genitalia ontogeny -- Homeobox 13 (Hox13) -- Fibroblast growth factors (Fgfs) -- Wingless (Wnt) signaling -- Sonic hedgehog (Shh) -- Androgen receptor (AR) -- Birth defects -- Hypospadias -- Cryptorchidism -- Conclusion -- Glossary -- Funding -- References -- Chapter 2: Developmental genetics of the female reproductive tract -- Introduction -- Embryogenesis of the female reproductive tract -- Development of ovaries -- Development of the Müllerian ducts -- Formation -- Initiation -- Invagination -- Elongation -- Sex determination and regression of the Wolffian duct -- Development of uterus, fallopian tubes, and upper vagina from Müllerian ducts -- Fusion -- Canalization -- Septal resorption -- Development of the vagina -- Ovarian anomalies -- Fallopian tube anomalies -- Uterine anomalies -- Classification of Mullerian duct anomalies -- Class I-Mullerian agenesis/hypoplasia -- Class II-Cervical agenesis -- Class III-Unicornuate -- Class IV-Didelphys -- Class V-Bicornuate -- Class VI-Septate.