Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts
MDPI - Multidisciplinary Digital Publishing Institute, 2018
Online
Buch, Datenträger, Online-Ressource
- 1 electronic resource (VI, 250 p.)
Zugriff:
- Evangelische Hochschule Rheinland-Westfalen-Lippe, Bibliothek (DE-956), Bibliothekskatalog
- FH Münster, Hochschulbibliothek (DE-836), Bibliothekskatalog
- Fachhochschule Dortmund, Hochschulbibliothek (DE-Dm13), Bibliothekskatalog
- Hochschulbibliothek der Fachhochschule Aachen (DE-A96), Bibliothekskatalog
- Hochschulbibliothek der Hochschule Düsseldorf (DE-Due62), Bibliothekskatalog
- Hochschule Hamm-Lippstadt, Bibliothek Hamm (DE-1871)
- Hochschule Koblenz, RheinAhrCampus, Bibliothek (DE-1105), Bibliothekskatalog
- Hochschule Niederrhein, Bibliothek (DE-829), Bibliothekskatalog
- Hochschule Ruhr West, Hochschulbibliothek (DE-1393), Bibliothekskatalog
- Ruhr-Universität Bochum, Universitätsbibliothek (DE-294), Bibliothekskatalog
- Technische Hochschule Georg Agricola, Hochschulbibliothek (DE-Bm1), Bibliothekskatalog
- Technische Hochschule Köln, Hochschulbibliothek (DE-832), Bibliothekskatalog
- Universitäts- und Landesbibliothek Bonn (DE-5), Bibliothekskatalog
- Universitäts- und Landesbibliothek Düsseldorf (DE-61), Bibliothekskatalog
- Universitäts- und Landesbibliothek Münster, Zentralbibliothek (DE-6), Bibliothekskatalog
- Universitätsbibliothek Dortmund (DE-290), Bibliothekskatalog
- Universitätsbibliothek Duisburg-Essen (DE-465), Bibliothekskatalog
- Universitätsbibliothek Paderborn (DE-466), Bibliothekskatalog
- Universitätsbibliothek Siegen (DE-467), Bibliothekskatalog
- Universitätsbibliothek Trier (DE-385), Bibliothekskatalog
- Universitätsbibliothek Wuppertal (DE-468), Bibliothekskatalog
- Universitätsbibliothek der Fernuniversität (DE-708), Bibliothekskatalog
- Universitätsbibliothek der RPTU in Kaiserslautern (DE-386), Bibliothekskatalog
- Universitätsbibliothek der RWTH Aachen (DE-82), Bibliothekskatalog
- ZB MED - Informationszentrum Lebenswissenschaften, Köln (DE-38M), Bibliothekskatalog
- Zentralbibliothek der Sportwissenschaften der Deutschen Sporthochschule Köln (DE-Kn41), Bibliothekskatalog
The year 2017 marks the 20th anniversary of the molecular cloning of the long sought-after capsaicin receptor, now known as TRPV1 (Transient Receptor Potential Vanilloid 1). This seminal discovery has opened up a "hot" new field of basic research and launched drug discovery efforts into the large family (by the latest count, 28 mammalian members and 27 in humans) of TRP ion channels. Indeed, it took less than a decade for the first potent, small molecule TRPV1 antagonists to enter phase 1 clinical trials, closely followed by TRPA1 and TRPM8 antagonists. The literature on TRP channels is immense. TRPV1 alone is a keyword in over 5000 publications searchable in PubMed. Clearly, it is not possible to capture the entire literature in a single thematic issue. Consequently, the selection of articles presented in this book represents a sampling of the literature, and is admittedly subjective. We tried to survey the wide range of human diseases in which TRP channels have been implicated, ranging from chronic pain through asthma and diabetes to cancer, and highlight the channels that appear to hold the greatest promise for therapeutic targeting. With this book, we hope to convince readers that TRP channels constitute a formidable family of potential therapeutic targets that will likely continue to demand attention
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Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts
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Autor/in / Beteiligte Person: | Szallasi, Arpad [Autor/in] ; Huang, Susan M. [Autor/in] |
Veröffentlichung: | MDPI - Multidisciplinary Digital Publishing Institute, 2018 |
Medientyp: | Buch |
Datenträgertyp: | Datenträger, Online-Ressource |
Umfang: | 1 electronic resource (VI, 250 p.) |
ISBN: | 9783038426387; 3038426385; 9783038426394; 3038426393 |
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